A lot of people show up at the border without knowing they have options. Here’s the short version:
San Ysidro is the most convenient if you’re headed to downtown Tijuana or arriving by trolley from San Diego. It has the most lanes and never closes, but the tradeoff is that it also tends to have the longest lines.
Otay Mesa is often the smarter choice for drivers, especially during peak hours. It’s a bit east of downtown Tijuana and handles a lot of commercial truck traffic, but passenger car wait times are frequently shorter than at San Ysidro. Worth the detour if you’re not in a hurry to get to the Zona Centro.
PedWest is pedestrian-only and closes at 2:00 PM sharp — which most people don’t find out until they’re already there. If you’re walking back from Tijuana in the afternoon, make sure you know your cutoff.
Cross Border Xpress (CBX) is a paid crossing — a literal bridge from a U.S. terminal directly into Tijuana’s international airport. It’s only for ticketed airline passengers, but if that’s you, it’s genuinely one of the most efficient things about flying out of TIJ.